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Disease course in a patient with TEN (SCORTEN 4) associated with cancer treatment. Disease progression was observed during high-dose intravenous methylprednisolone treatment and the patient developed persistent hyperglycaemia. JAK1i rescue therapy with abrocitinib was initiated on day 4, resulting in visible cessation of progression within 48 h and initial re-epithelialization within 4 days. Top, photographs of the back of the patient, showing the degree of re-epithelialization at the indicated timepoints after hospital admission. Bottom, Treatment schedule. Arrow marks start of abrocitinib treatment. Study: Spatial proteomics identifies JAKi as treatment for a lethal skin disease

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